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KMID : 0360319940260020285
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 2 p.285 ~ p.295
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Studies on the H2B Histone, c-Myc and DNA Topoisomerase I Gene Expression during HL-60 Differentiation by All-Trans Retinoic Acid
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임규
박정동/최병한/이용진/김계영/이명선/장은미/김삼용/권기량
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Abstract
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Effects of all-trans retinoic acid(retinoic acid) on DNA replication, H2B histone and DNA topoisopmerase I(Topo I) gene expression have been investigated in human promyelocytic leukemia cell line HL-60. DNA synthesis decreased at 24 hours after
exposure
of retinoic acid in the HL-60 cells. H2B histone mRNA rapidly reduced at 48 hours and Topo I and c-myc mRNA at 24 hours in retinoic acid-exposured HL-60 cells, respectively. the levels of c-myc, H2B histone and Topo I gene expression were reduced
in
proportion to the concentration of retinoic acid. The H2B histone mRNA in retinoic acid-exposured cells was elevated by cycloheximide treatment, while the level of Topo I mRNA was constant.
These results suggest that regulations of H2B histone, c-myc and Topo I gene expression are different from one another, and repression of Topo I gene is closely correlated with c-myc gene during retinoic acid-induced differentiation of HL-60
cells.
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